| # |
| 10Fold Communicationsnot edited since 2017 | 2590 Walnut Street, Five Points | | | |
| 3inot edited since 2017 | 3509 Ringsby Court, Globeville | | | |
| A |
| Aetnanot edited since 2020 | 1500 Wynkoop Street, Highland | | | |
| AIMMnot edited since 2019 | 2001 Lincoln Street, North Capitol Hill | aimm.online | +1-720-261-4458 | |
| Alerio Technology Groupnot edited since 2020 | 7808 East Cherry Creek South Drive, University Hills | | | |
| Asynchrony Labsnot edited since 2020 | 2300 15th Street, Highland | | | |
| Autodesk | 1550 16th Street, Highland | | | |
| B |
| Big Footprintnot edited since 2019 | 1045 Lincoln Street, Civic Center | | | |
| Boa Fit Systemnot edited since 2018 | 3575 Ringsby Court, Globeville | | | |
| BWBacon Groupnot edited since 2017 | 621 Kalamath Street, La Alma–Lincoln Park | | | |
| C |
| CaptainUnot edited since 2017 | 910 Santa Fe Drive, La Alma–Lincoln Park | | | |
| Cirro Web Designnot edited since 2017 | 2500 Larimer Street, Five Points | | | |
| Clancy Systems International Inc. | 2149 South Grape Street, University Hills | clancysystems.com | +1-303-753-0197 | |
| CommutePaysnot edited since 2017 | 1732 Wazee Street, Highland | | | |
| Company Benot edited since 2017 | 621 Kalamath Street, La Alma–Lincoln Park | | | |
| Consume & Createnot edited since 2017 | 3300 Walnut Street, Cole | | | |
| D |
| Democracy Worksnot edited since 2017 | 1507 Blake Street, Highland | | | |
| F |
| Faction, Inc.not edited since 2017 | 303 East 17th Avenue, North Capitol Hill | | | |
| Four Winds Interactivenot edited since 2017 | 1221 Broadway, Civic Center | | | |
| G |
| General Assemblynot edited since 2017 | 3858 Walnut Street, Cole | | | |
| H |
| Hold Fast Creativenot edited since 2017 | 612 Washington Street, Capitol Hill | | | |
| I |
| Ideas By Naturenot edited since 2017 | 1009 Grant Street, Capitol Hill | | | |
| InterAct Softwarenot edited since 2017 | 1776 Lincoln Street, North Capitol Hill | | | |
| L |
| Levels Beyondnot edited since 2017 | 2710 Walnut Street, Five Points | | | |
| M |
| Matillion | 1200 17th Street, Civic Center | matillion.com | +1-720-930-4647 | |
| Maxwell Financial Labsnot edited since 2018 | 518 17th Street, Civic Center | | | |
| Media Saga Social SEO | 1880 Arapahoe Street, North Capitol Hill | mediasagasocialseo.com | +1-720-205-9771 | |
| Mobile-DInot edited since 2022 | 3327 Brighton Boulevard, Globeville | mobile-di.com | +1-720-771-1933 | |
| Mocapay | 1660 17th Street, Highland | | | |
| N |
| Native Ranknot edited since 2022 | 1055 Auraria Parkway, Jefferson Park | nativerank.com | +1-303-524-3836 | |
| Neighborhood Link, Inc.not edited since 2020 | 2546 15th Street, Highland | | | |
| Nimblnot edited since 2018 | 800 Kalamath Street, La Alma–Lincoln Park | | | |
| Nuclear Networkingnot edited since 2017 | 100 Fillmore Street, Cheesman Park | nuclearnetworking.com | | |
| O |
| Orbit Design - Web Designnot edited since 2021 | 2560 Sheridan Boulevard, Sloan Lake | orbit-design.com | | |
| P |
| PaySimplenot edited since 2018 | 1515 Wynkoop Street, Highland | | | |
| Pix4D | 1615 Platte Street, Highland | pix4d.com | +1-720-204-8069 | |
| PlaceWise Digitalnot edited since 2017 | 1390 Lawrence Street, La Alma–Lincoln Park | | | |
| R |
| RealEyes Medianot edited since 2017 | 940 Logan Street, Capitol Hill | | | |
| Redbot Securitynot edited since 2022 | 600 17th Street, Civic Center | redbotsecurity.com | +1-866-473-3268 | |
| S |
| Salesforce | 1225 17th Street, North Capitol Hill | | | |
| Sidekick Web Studionot edited since 2019 | 1415 Park Avenue West, Five Points | sidekickwebstudio.com | +1-303-225-9372 | |
| Signpostnot edited since 2017 | 2363 Blake Street, Five Points | | | |
| Something Independentnot edited since 2017 | 621 Kalamath Street, La Alma–Lincoln Park | | | |
| T |
| Techimon | 1312 17th Street, Civic Center | techimon.com | +1-303-566-0373 | |
| Techstarsnot edited since 2018 | 3575 Ringsby Court, Globeville | | | |
| The SEO Expertnot edited since 2017 | 100 Fillmore Street, Cheesman Park | thesearchengineoptimizationexpert.com | +1-303-997-2222 | |
| W |
| Wazee Digitalnot edited since 2017 | 1515 Lawrence Street, Civic Center | | | |
| Website Designs Denvernot edited since 2017 | 800 West 9th Avenue, La Alma–Lincoln Park | | | |
| WP Support And Maintenance | 3000 Lawrence Street, Five Points | wpsupportandmaintenance.com | +1-303-351-2423 | |
| X |
| XO Communicationsnot edited since 2017 | 1660 Lincoln Street, North Capitol Hill | | | |
